On April 25, 1953, James D. Watson and Frances H.C. Crick announced the structure of DNA in the journal, Nature. Unlike many scientific papers, this one had a simple title: A Structure for Deoxyribose Nucleic Acid.
Fifty years has gone by; a lot has changed. Today we have sequenced the human genome.
I recommend James Watson's personal account of the discovery, The Double Helix. It's an interesting read.